Results from the present investigation indicate that many college students did not demonstrate high involvement in organized religion. Yet they reported high levels of spiritual well-being, especially existential well-being, and low levels of suicidal ideation. Furthermore, results highlighted existential well-being as an important factor associated with lower levels of suicidal ideation among college students. Overall, these findings suggest that a strategy for reducing distress and preventing suicide among college students may involve exploring mechanisms that nurture a sense of meaning in life in individuals for whom organized religion remains unimportant. Health professionals may have more success in improving young people’s sense of meaning and purpose by methods other than an increase in faith, participation in organized religion, or other indicators of religiosity.